From personalized medicine to personalized justice: the promises of translational pharmacogenomics in the justice system.
نویسندگان
چکیده
syndrome, was treated with methyl phenidate, clonidine and fluoxetine [10]. Over a 10‐month period, he developed gastrointestinal toxicity, incoordination and disorientation, and sei‐ zures. He died from a cardiac arrest. Post‐ mortem toxicology showed high fluoxetine and norfluoxetine concentrations, and PGx revealed a poor CYP2D6 metabolizer geno‐ type, resulting in fluoxetine accumulation and toxicity. Subsequently, the boy’s parent were absolved from involvement in fluoxetine intoxication. Another example is genotyping uridine 5́ ‐diphosphate‐glucuronyltransferase 1A1 for patients medicated with irinotecan to avoid hematopoietic toxicity [11];
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ورودعنوان ژورنال:
- Pharmacogenomics
دوره 11 6 شماره
صفحات -
تاریخ انتشار 2010